| Autor: |
Powell, Barry, Crocker, Lesley, Rogers, George |
| Zdroj: |
Mitochondrial DNA: The Journal of DNA Mapping, Sequencing, and Analysis; 1993, Vol. 3 Issue: 6 p401-405, 5p |
| Abstrakt: |
The Intermediate Filament (IF) superfamily comprises several multigene families, of which the two keratin families are the largest. The keratin IF genes are expressed in epithelial tissues in differentiation-specific patterns and recently we reported the sequence and expression of a hair IF type II keratin gene (KRT2.9). Two related genes were present in the cosmid containing KRT2.9 and we have now sequenced one of them and found that it encodes a hair-like IF type (I protein (KRT2.13). However, KRT2.13 is not expressed in the hair follicle. Interestingly there is significant sequence homology between introns 1, 5 and 6 of KRT2.13 and KRT2.9 to suggest gene conversion of these regions or possibly conservation of functional sequences. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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