| Autor: |
Sawai, Sadako, Fukui, Hiroyuki, Fukuda, Masakatsu, Wang, Nai Ping, Wada, Hiroshi, Manabe, Reizo |
| Zdroj: |
Current Eye Research; 1991, Vol. 10 Issue: 8 p713-718, 6p |
| Abstrakt: |
The presence of histamine Hi-receptors in the bovine retinal blood vessels was studied with a [3H]mepyramine binding assay. The membranes of purified vessels obtained from bovine retinas showed specific [3H]mepyramine binding sites with a dissociation constant(K0) of 2.78±0.32 nM. This was similar to values obtained from the retinal neuronal fractions. The binding capacity(Bmax) was 53.8±1.7 f'mol/mg protein, which was about a half that of the retinal neuronal fractions (108.9±3.1 f'mol/mg protein). Some Ht-antagonists proved to be potent competitors for [3H]mepyramine binding sites in bovine retinal blood vessels. These results indicate that histamine Hi-receptors exist in the retinal blood vessels which may be involved in the physiological and the pathological responses of blood circulation in retinas. |
| Databáze: |
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