| Autor: |
Campbell, Berry, Newman, Roger, Eller, Daniel, Cox, Susan, Roussis, Periclis, Horn, E. J., Stramm, Sue |
| Zdroj: |
Journal of Maternal-Fetal and Neonatal Medicine; 1995, Vol. 4 Issue: 1 p35-38, 4p |
| Abstrakt: |
Second-trimester labor induction is frequently complicated by significant morbidity. Although instrumental dilatation and evacuation is considered the safest method for second-trimester pregnancy termination, most younger physicians lack experience with this procedure. As a result, many physicians use vaginal prostaglandin suppositories for second trimester labor induction. Unfortunately, systemic side effects and in-complete abortion are common complications. We sought to compare the side effects and efficacy of intra-amniotic 15-methyl prostaglandin F2α (PGF2α) with intravaginal prostaglandin E2 (PGE2) for second-trimester labor induction. We compared outcomes in patients receiving intravaginal PGE2 (group A, N = 24) with intra-amniotic 15-methyl prostaglandin F2α (group B, N = 25) for midtrimester labor induction. Group A patients received intravaginal PGE2 20 mg every 3-4 hr, and group B patients received intra-amniotic 15-methyl PGF2α 2.5 mg. Eighty-eight percent of patients in group A successfully delivered by 24 hr, and all did by 36 hr. Eight patients in group A required surgical intervention due to incomplete abortion. Likewise, 96% and 100% of group B patients delivered within 24 and 36 hr, respectively. Only 1 patient in group B had an incomplete abortion. Significant gastrointestinal side effects were noted more often in group A than in group B patients (P < 0.001). The efficacy of intra-amniotic 15-methyl PGF2α for second trimester labor induction is confirmed in this study with significantly fewer systemic side effects and fewer cases requiring surgical intervention. |
| Databáze: |
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