Increased peripheral blood gamma delta T-cells in patients with lymphoid neoplasia: A diagnostic dilemma in flow cytometryThis article is a US government work and, as such, is in the public domain in the United States of America

Autor: McClanahan, Julie, Fukushima, Paula I., Stetler-Stevenson, Maryalice
Zdroj: Cytometry Part B: Clinical Cytometry; 15 December 1999, Vol. 38 Issue: 6 p280-285, 6p
Abstrakt: We have observed increased numbers of non-neoplastic γδ-T-cells in the peripheral blood of a series of patients with non-Hodgkin's lymphoma not of γδ–T-cell origin. The majority of normal γδ–T-cells are negative for surface CD4 and CD8 and a subpopulation does not express CD5, two immunophenotypic findings strongly suggestive of neoplasia in alpha beta T-cells. In addition, they express cytotoxic T-cell/Natural killer cell antigens. In this study, up to 22% of PBLs were CD4 and CD8 negative γδ–T-cells and up to 33% PBLs were CD5 negative γδ–T-cells. In addition, as high as 42% of PBLS were γδ–T-cells expressing cytotoxic T-cell/Natural killer cell antigens, suggestive of a large granular lymphoproliferative disorder. Failure to recognize that these are normal γδ–T-cells could lead to the erroneous diagnosis of peripheral blood involvement with a T-cell neoplasm, especially in the setting of a history of non-Hodgkin's lymphoma. Cytometry (Comm. Clin. Cytometry) 38:280–285, 1999. Published 1999 Wiley-Liss, Inc.
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