| Autor: |
Toyooka, Kazuhiko, Muratake, Tatsuyuki, Tanaka, Toshihisa, Igarashi, Shuichi, Watanabe, Hiromi, Takeuchi, Hiromori, Hayashi, Shigenobu, Maeda, Masaya, Takahashi, Makoto, Tsuji, Shoji, Kumanishi, Toshiro |
| Zdroj: |
American Journal of Medical Genetics. Part A; 16 April 1999, Vol. 88 Issue: 2 p164-167, 4p |
| Abstrakt: |
Recent genetic analyses have suggested a linkage between schizophrenia and the chromosomal region 22q12q13. 14-3-3 protein, abundant in the brain, mediates interactions between diverse molecules of biological activities; its gene was recently mapped to chromosome 22q12.1q13.1. We therefore investigated allele frequencies of a variable number of tandem repeat (VNTR) in the 5'-noncoding region of the 14-3-3 η chain gene in controls and schizophrenics. The frequencies of the two-repeat allele were significantly higher (P < 0.05) in the schizophrenics, and particularly in those with onset before age 22 (early-onset schizophrenics, P < 0.02), than in the controls. The odds ratio was significantly increased in the early-onset schizophrenics homozygous for the two-repeat allele (OR = 3.3, 95% CI = 1.19.7). The 14-3-3 η chain gene is a potential susceptibility gene for schizophrenia, and particularly for early-onset schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:164167, 1999. © 1999 Wiley-Liss, Inc. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
