In vitrostudy of the antioxidant properties of nimesulide and 4-OH nimesulide: effects on HRP- and luminol-dependent chemiluminescence produced by human chondrocytes

Autor: Zheng, S.X, Mouithys-Mickalad, A, Deby-Dupont, G.P, Deby, C.M.-T, Maroulis, A.P, Labasse, A.H, Lamy, M.L, Crielaard, J.-M.R, Reginster, J.-Y.L, Henrotin, Y.E
Zdroj: Osteoarthritis and Cartilage; November 2000, Vol. 8 Issue: 6 p419-425, 7p
Abstrakt: ObjectivesReactive oxygen species (ROS) are now recognized to play an important role in the pathogenesis of rheumatic diseases and constitute an interesting therapeutic target for drugs. This in vitrostudy was designed to evaluate the antioxidant properties of nimesulide (NIM), a nonsteroidal antiinflammatory drug of the sulfonanilide class, and its main metabolite 4-OH nimesulide (4-OHNIM).
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