| Autor: |
Li, Yu-feng, Zhu, Jia-bin, Wang, Chun-ling, Ding, Bang-he, Li, Yuan-yuan, Xuan, Heng-bao, Qian, Mo-sheng |
| Zdroj: |
Chinese Journal of Cancer Research; June 2005, Vol. 17 Issue: 2 p150-153, 4p |
| Abstrakt: |
Abstract: Objective: To observe the long-term effect of homoharringtonine (HHT) on chronic granulocytic leukemia (CGL) and its pharmacological mechanism. Methods: 76 patients with newly diagnosed early chronic phase CGL received treatment of merely 1.5 mg/m2 daily HHT for induction remission and long-term maintenance treatment. The apoptosis rate of bone marrow CD34+ cells induced by HHT was assayed with flow cytometer. Results: 86.8% patients achieved CHR, 13.2% patients PHR and 31.8% patients got cytogenetic response in HHT treatment group, which was longer than 31 (8–54) months in hydroxyurea (HU) group (P<0.05). The effect of apoptosis induction HHT was stronger on CGL-CP patients bone marrow CD34+ cells than on normal person bone marrow CD34+ cells. Conclusion: HHT is a very effective drug for remission induction and long-term maintenance treatment in early chronic phase CGL patients. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink