| Autor: |
Feng, Jian-wei, Chen, Yi-rong, Shi, Bao-guang, Yan, Dong-wen, Wagn, Jin-sui |
| Zdroj: |
Chinese Journal of Cancer Research; June 2005, Vol. 17 Issue: 2 p127-131, 5p |
| Abstrakt: |
Abstract: Objective: To study the expression of dendritic cells in human renal cell carcinoma and explore the cause, so to reveal the mechanism of escaping immune surveillance in RCC. Methods: The expressions of CD83+DCs, CD1a+DCs,VEGF and TGF-β1 in tumoral, peritumoral and normal kidney tissues of RCC in 30 cases were detected by immunohistochemistry using streptavidin/peroxidese(SP) Results: CD83+DCs were mainly located in the peritumoral areas; whereas CD1a+DCs were mainly retained within the cancer nests. The number of CD83+DCs was inversely correlated with the clinical stage (P<0.05); but there were no significant correlations between the number of CD1a+DCs and the clinical stage (P>0.05). The expressions of CD83+DCs and CD1a+DCs have significant difference between the tumoral, peritumoral and normal kidney tissues(P<0.001). The expression of VEGF and TGF-β1 were significantly lower in samples with highly infiltrating CD83+DCs(P<0.05); Whereas CD1a+DCs were not (P>0.05). Conclusion: DC has the tendency to gathering in tumor, but because of the immunosuppressive cytokins, for example VEGF and TGF-β1, inhibits the maturation of DC, there are less mature TIDCs(CD83+TIDCs) in the tumoral tissues, they are mainly located in the peritumoral areas. This may contribute to the mechanism of escaping immune surveillance in RCC. |
| Databáze: |
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