| Autor: |
Cao, Shugeng, J. Brodie, Peggy, S. Miller, James, Ratovoson, Fidy, W. Callmander, Martin, Randrianasolo, Sennen, Rakotobe, Etienne, E. Rasamison, Vincent, M. Suh, Edward, TenDyke, Karen, G. I. Kingston, David |
| Zdroj: |
Journal of Natural Products; June 2007, Vol. 70 Issue: 6 p1064-1067, 4p |
| Abstrakt: |
Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendronsp. led to the isolation of two new cardenolides, elaeodendrosides T and U (1and 2). The structures of the new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 3, 4, and 5showed significant antiproliferative activity against A2780 human ovarian cancer cells with IC50values of 0.085, 0.019, 0.19, and 0.10 M, respectively, while compounds 2and 6were less active. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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