Revealing Coupling Patterns in Isoprenoid Alkylation Biocatalysis
| Autor: | T. Walsh, Christopher |
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| Zdroj: | ACS Chemical Biology; May 2007, Vol. 2 Issue: 5 p296-298, 3p |
| Abstrakt: | Diversity of scaffold structure and function is a hallmark of the >50,000 isoprenoid natural products such as taxol. Whereas most members of this class are assembled by iterative head-to-tail enzymatic joining reactions between Δ 2- and Δ 3-isopentenyl diphosphate (IPP) monomers, dimerization of two Δ 2-IPP molecules has now been shown to account for three additional modes of “irregular” coupling patterns at the level of C 10monoterpene scaffolds. |
| Databáze: | Supplemental Index |
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