In-vivomonitoring of corticomedullary nephrocalcinosis in rats using computerized tomography

Autor: Grimm, P., Nowitzki-Grimm, S., Weidenmaier, W., Schumacher, K. A., Classen, H. G.
Zdroj: Laboratory Animals; October 1991, Vol. 25 Issue: 4 p354-359, 6p
Abstrakt: An in-vivomethod, computerized tomography (CT), was used to monitor nephrocalcinosis in female rats. CT density data correlated well with renal Ca content measured by atomic absorption spectrophotometry.In-vivoCT measurements revealed that the severity of nephrocalcinosis may change spontaneously with time. Manifest calcifications may exhibit spontaneous regression and are probably affected positively by high dietary Mg, in contrast to increased Ca. It is concluded that CT is a suitable and reliable non-invasive in vivomethod to follow up time-dependent alterations in kidney calcifications in rats.
Databáze: Supplemental Index