Anticancer and Immuno-Modulating Properties of Cyclophosphazenes

Autor: Labarre, Jean-François, Sournies, François, Guerch, Guy, Bakili, Abdelaziz El, Bonnet, Jean-Pierre, Castera, Pierre, Faucher, Jean-Paul, Graffeuil, Marcel
Zdroj: Phosphorus, Sulfur, and Silicon and the Related Elements; January 1989, Vol. 41 Issue: 1 p167-179, 13p
Abstrakt: Clinical uses of aziridinocyclophosphazenes ("nude" drugs) as anticancer immuno-modulating drugs are severely limited by hematological toxicity. Benefits from vectorization through covalent linkage to biogenic polyamines as tumor finders are evidenced and further improvements through monoclonal antibodies are envisaged.
Databáze: Supplemental Index