| Autor: |
Hughes, F., Jr., Grossman, R. B. |
| Zdroj: |
Organic Letters; September 2001, Vol. 3 Issue: 18 p2911-2914, 4p |
| Abstrakt: |
Nitrogen-containing tethered diacids, easily prepared by reductive alkylation of diethyl aminomalonate or ethyl cyanoglycinate, undergo double Michael reactions with 3-butyn-2-one to give highly functionalized and substituted piperidines (pipecolic acid derivatives) with surprisingly high stereoselectivity. The heterocyclic double Michael adducts can be induced to undergo further cyclizations to give a variety of azabicyclic and diazabicyclic compounds. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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