| Autor: |
Dales, N. A., Bohacek, R. S., Satyshur, K. A., Rich, D. H. |
| Zdroj: |
Organic Letters; July 2001, Vol. 3 Issue: 15 p2313-2316, 4p |
| Abstrakt: |
The design, synthesis, and enzyme inhibition of a new class of aspartic peptidase inhibitors is described. Unsymmetrical ureas were designed from computer-generated structures. Using mechanism-based and substrate-based design techniques, potent pepsin inhibitors were developed and the binding mode was established. Two X-ray crystal structures of enzyme-bound inhibitors revealed a new binding mode that is closely related to the computer-generated binding mode. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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