Double Protection of the Heterocyclic Base of Xanthosine and 2'-Deoxyxanthosine

Autor: Van Aerschot, A., Mag, M., Herdewijn, P., Vanderhaeghe, H.
Zdroj: Nucleosides and Nucleotides; January 1989, Vol. 8 Issue: 2 p159-178, 20p
Abstrakt: Reaction of O-protected xanthosines with p-nitrophenyl ethanol under Mitsunobu conditions yields the doubly alkylated O2,O6- and N1-,O2-derivatives. Deoxyxanthosine protected on both oxygens with a 2-(4-nitrophenyl)-ethyl group was synthesized starting from deoxyguanosine. Both protecting groups can be eliminated with DBU in pyridine.
Databáze: Supplemental Index