| Autor: |
Kamaike, Kazuo, Takahashi, Mihoko, Utsugi, Kazuyuki, Tomizuka, Kazue, Okazaki, Yasunori, Tamada, Yuri, Kinoshita, Kazutomo, Masuda, Hiroyuki, Ishido, Yoshiharu |
| Zdroj: |
Nucleosides and Nucleotides; January 1996, Vol. 15 Issue: 1 p749-769, 21p |
| Abstrakt: |
Nucleophilic substitution reactions of 4-azolyl-1 β-P-D-ribofuranosylpyrimidin-2(1H)-one and 6-azolyl-9-β-D-ribofuranosyl-9H-purine derivatives, which were converted from uridine and inosine, with [15N]phthalimide in the presence of triethylamine or DBU gave N4-phthaloyl[4-15N]cytidine and N6-phthaloyl[6-15N]- adenosine derivatives, respectively, in high yields. Similar reactions of those azolyl derivatives with succinimide afforded N4-succinylcytidine and N6-succinyladenosine derivatives in high yields. The corresponding 2'-deoxyribonucleosides were also synthesized efficiently through the same procedure. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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