| Autor: |
McCauley, J. A., Theberge, C. R., Liverton, N. J. |
| Zdroj: |
Organic Letters; October 2000, Vol. 2 Issue: 21 p3389-3391, 3p |
| Abstrakt: |
The dramatic effect of base on the chemoselectivity of the reaction of amidines with substituted 3-phenyl-2-propynylnitriles is demonstrated. Amidine 1 can be added to cyanoalkyne 2 to give iminopyrimidine isomer 3 with high selectivity. The addition of 2 equiv of NaHMDS completely reverses the selectivity of the reaction, yielding isomer 4 almost exclusively. This method has been used to prepare a variety of substituted 4-iminopyrimidines. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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