Synthesis and Conformation of Gly-Gly Dipeptides Constrained with Phenylalanine-like Aminocaproic Acid Linkers

Autor: MacDonald, M., Velde, D. Vander, Aube, J.
Zdroj: Organic Letters; June 2000, Vol. 2 Issue: 12 p1653-1655, 3p
Abstrakt: The constraint of dipeptides with linkers derived from 6-aminocaproic acid (Aca) is a useful means of constructing a β-turn peptidomimetic. The extension of this concept to the mimicry of a tripeptide entails the incorporation of a side chain moiety on either end of the Aca chain. The synthesis and conformational analysis of two exemplary compounds is discussed.
Databáze: Supplemental Index