| Autor: |
Kojima, N., Bruice, T. C. |
| Zdroj: |
Organic Letters; January 2000, Vol. 2 Issue: 1 p81-84, 4p |
| Abstrakt: |
Replacement of the negatively charged phosphodiester linkages of RNA with positively charged guanidinium linkages provides the polycationic ribonucleic guanidine (RNG). RNG is anticipated to bind strongly to target DNA/RNA through the specific interactions of nucleobases and the attractive electrostatic interactions of backbones. Preparation of building blocks and the solid-phase synthesis of RNG are reported. Both trimeric and pentameric uridyl RNG have been synthesized. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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