| Autor: |
Garcia-Garibay, M. A., Houk, K. N., Keating, A. E., Cheer, C. J., Leibovitch, M., Scheffer, J. R., Wu, L.-C. |
| Zdroj: |
Organic Letters; October 1999, Vol. 1 Issue: 8 p1279-1281, 3p |
| Abstrakt: |
To better understand the forces controlling chemical reactions in crystals, the absolute asymmetric photorearrangement of 4-m-chlorobenzyloxy-2-pyridone leading to the corresponding enantiomerically enriched (78% ee) β-lactam was modeled computationally using a flexible minilattice consisting of a central reactant and 20 nearest and 72 next-nearest neighbors. The computational results predicted a preference for formation of the (R,R)-enantiomer, and this was verified experimentally by absolute configuration correlation studies. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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