| Autor: |
Liang, B., Portonovo, P., Vera, M. D., Xiao, D., Joullie, M. M. |
| Zdroj: |
Organic Letters; October 1999, Vol. 1 Issue: 8 p1319-1322, 4p |
| Abstrakt: |
Tamandarin A (1), a newly isolated natural product similar in structure to didemnin B (2), was shown to be somewhat more active in vitro than 2 against pancreatic carcinoma with an ED50 value 1.5 to 2 ng/mL. We report here the first total synthesis of 1. The key steps include a practical stereoselective synthesis of the Hiv-isostatine unit, high-yielding linear precursor formation, a successful macrocyclization, and coupling of the macrocycle with the side chain to afford tamandarin A (1). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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