| Autor: |
Boldi, A. M., Dener, J. M., Hopkins, T. P. |
| Zdroj: |
Journal of Combinatorial Chemistry; July 9, 2001, Vol. 3 Issue: 4 p367-373, 7p |
| Abstrakt: |
The library synthesis of alkoxyprolines was achieved using an acid-stable, nucleophile-cleavable solid support. A hydroxythiophenol linker derived from Merrifield resin was esterified with the corresponding ethers of BOC-hydroxyproline. Removal of the BOC protecting group with trifluoroacetic acid followed by acylation gave solid-supported hydroxyproline derivatives. Cleavage from the solid support with excess primary amines or excess secondary amines followed by purification of the crude products from the excess amine by supported liquid−liquid extraction gave the alkoxyproline library in high purity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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