| Autor: |
Chen, Y., Killday, K. B., McCarthy, P. J., Schimoler, R., Chilson, K., Selitrennikoff, C., Pomponi, S. A., Wright, A. E. |
| Zdroj: |
Journal of Natural Products; February 23, 2001, Vol. 64 Issue: 2 p262-264, 3p |
| Abstrakt: |
Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide−lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 μg/mL (SDB) and 3.1 μg/mL (RPMI) for 3, and 25 μg/mL (SDB) and 6.25 μg/mL (RPMI) for 4, respectively. Both also showed moderate in vitro inhibition of Aspergillus fumigatus with IC90's of 25 μg/mL. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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