| Autor: |
Schmitzer, P. R., Graupner, P. R., Chapin, E. L., Fields, S. C., Gilbert, J. R., Gray, J. A., Peacock, C. L., Gerwick, B. C. |
| Zdroj: |
Journal of Natural Products; June 23, 2000, Vol. 63 Issue: 6 p777-781, 5p |
| Abstrakt: |
2,4-Dihydro-4-(β-d-ribofuranosyl)-1,2,4(3H)-triazol-3-one (2) was identified as the principal phytotoxic component of a fermentation broth derived from an Actinomadura. The compound is a new natural product, but known by synthesis. Broad-spectrum herbicidal activity was demonstrated in greenhouse tests. Metabolite reversal studies suggested the target site was adenylosuccinate synthetase, which was confirmed by direct measurement of the activity of the 5-phosphorylated derivative on the isolated enzyme. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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