| Autor: |
Garbe, T. R., Kobayashi, M., Shimizu, N., Takesue, N., Ozawa, M., Yukawa, H. |
| Zdroj: |
Journal of Natural Products; May 26, 2000, Vol. 63 Issue: 5 p596-598, 3p |
| Abstrakt: |
The novel indole derivatives 2,2-bis(3,3-indolyl)propionic acid (1); 1,1,1,-tris(3,3,3-indolyl)ethane (2); and 2,2-bis(3,3-indolyl)isocaproic acid (3) were isolated from solvent extracts of indole-supplemented supernatants of Escherichia coli and corynebacteria. The compounds were also obtained by chemical synthesis: compounds 1 and 2 from indole and pyruvic acid and compound 3 from indole and α-ketoisocaproic acid, following incubation at 37 °C in aqueous medium. Tryptophan and pyruvic acid gave the novel 2-(2-tryptophanyl)lactic acid (4). The condensation reaction between indoles and α-keto acids was of general nature, and the mild reaction conditions suggested it may proceed in vivo. Examples for endogenous occurrence may be the neuro-degenerative diseases phenylketonuria and maple syrup urine disease, both characterized by elevated blood levels of α-keto acids. |
| Databáze: |
Supplemental Index |
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