| Autor: |
Nunes, R. L., Bieber, L. W., Longo, R. L. |
| Zdroj: |
Journal of Natural Products; December 27, 1999, Vol. 62 Issue: 12 p1643-1645, 3p |
| Abstrakt: |
The synthesis of mansonone F (1), an antimicrobial sesquiterpenequinone, is described. Starting from 2,5-dimethyl-1,4-naphthoquinone (5), the corresponding selectively protected hydroquinone 9 was prepared in four steps. Alkylation of 9 using chloroacetone, cyclization, and oxidation to the o-quinone completed the reaction sequence in 7.5% overall yield. The regioselectivity for the basic hydrolysis of hydroquinone diacetate 6 was discussed on the basis of MO calculations. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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