A 1,4-Disubstituted Quinolizidine from a Madagascan Mantelline Frog (Mantella)

Autor: Jain, P., Garraffo, H. M., Yeh, H. J. C., Spande, T. F., Daly, J. W., Andriamaharavo, N. R., Andriantsiferana, M.
Zdroj: Journal of Natural Products; December 23, 1996, Vol. 59 Issue: 12 p1174-1178, 5p
Abstrakt: A major alkaloid, 217A, in skin extracts of a mantelline frog (Mantella baroni) was isolated by HPLC and the structure defined by 1H-NMR spectral analysis as (1R,4S,10S)- or (1R,4R,10R)-1-methyl-4-(Z)-(1-pent-2-en-4-ynyl) quinolizidine (1). Four other alkaloids&sbd;207I (2), 231A (3), 233A (4), and 235E‘ (5)&sbd;detected in frog skin extracts are proposed to be 1,4-disubstituted quinolizidines based on diagnostic mass and FTIR spectra.
Databáze: Supplemental Index