| Autor: |
Herr, R. J., Zhichkin, P., Hernandez-Abad, P. E., Meckler, H., Schow, S. R. |
| Zdroj: |
Organic Process Research & Development; July 2001, Vol. 5 Issue: 4 p442-444, 3p |
| Abstrakt: |
A process for the multikilogram preparation of 2-hydroxyethyl N,N,N,N-tetrakis(2-chloroethyl)phosphorodiamidate has been achieved in substantially pure form by a short synthetic sequence starting from phosphorus oxychloride and 2 equiv of bis(2-chloroethyl)amine. This process involves a two-step preparation of the intermediate mustard chloride in one pot, followed by the base-catalyzed reaction with excess ethylene glycol. This method has been carried out to provide 2.9 kg of this key drug substance intermediate in 52% overall yield. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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