| Autor: |
Faulconbridge, S. J., Holt, K. E., Lock, C. J., Taylor, S. J. C., Woods, M. |
| Zdroj: |
Organic Process Research & Development; November 2000, Vol. 4 Issue: 6 p563-566, 4p |
| Abstrakt: |
Dipeptides are important intermediates in many pharmaceutical products. To support a research programme on matrix metalloproteinases (MMP) we needed to prepare the dipeptide, Leu-Phe-NHMe (3). Chemical methods provided the material but not to the quality required, and thus an alternative preparation was sought. The use of enzymes in chemical synthesis was a tool that we had used before but not in the preparation of dipeptides. This contribution will show the utility of PeptiCLEC-TR in the preparation of dipeptide (3) and its application to other dipeptides. It will highlight the amenability of PeptiCLEC-TR to scale-up and demonstrate the recycling of this enzyme, which will make this a cost-effective route. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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