| Autor: |
Woods, M., Dyer, U. C., Andrews, J. F., Morfitt, C. N., Valentine, R., Sanderson, J. |
| Zdroj: |
Organic Process Research & Development; September 2000, Vol. 4 Issue: 5 p418-426, 9p |
| Abstrakt: |
An efficient resolution process using N-methyl glucamine (meglumine) which directly provides (S)-etodolac as the meglumine salt is described. This salt is also a dosage form with improved absorption characteristics. The off-isomer is efficiently racemised via the ester, prepared by mild esterification, followed by hydrolysis affording rac-etodolac suitable for recycling. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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