| Autor: |
Kuenburg, B., Czollner, L., Frohlich, J., Jordis, U. |
| Zdroj: |
Organic Process Research & Development; November 1999, Vol. 3 Issue: 6 p425-431, 7p |
| Abstrakt: |
(−)-Galanthamine has been synthesised using an efficient nine-step procedure, which in large scale affords 12.4 (6.7−19.1)% overall yield. The process improvements and optimization of each step are described. Notable steps include (i) an oxidative phenol coupling and (ii) crystallisation-induced chiral conversion of (±)-narwedine to (−)-narwedine. This is a practical and cost-effective synthesis of (−)-galanthamine which is amenable to pilot plant scale-up to afford sufficient material for use in clinical trials. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
