| Autor: |
Gijsen, H. J. M., Bakel, H. C. C. K. v., Zwaan, W., Hulshof, L. A. |
| Zdroj: |
Organic Process Research & Development; January 1999, Vol. 3 Issue: 1 p38-43, 6p |
| Abstrakt: |
A scaleable process for the chlorination of 5-amino-2,4,6-triiodoisophthalic acid to the corresponding acid chloride, a building block for the synthesis of iodinated X-ray contrast agents, has been developed. Two dimeric byproducts have been isolated and assigned structures consistent with an amide and an anhydride. Hydrolysis of the N-sulfinyl intermediate and simultaneous crystallisation of the phthalic acid chloride have been optimised by applying fractional factorial design. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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