| Autor: |
Manfredini, Stefano, Baraldi, PierGiovanni, Bazzanini, Rita, Durini, Elisa, Vertuani, Silvia, Pani, Alessandra, Marceddu, Tiziana, Demontis, Francesca, Vargiu, Laura, La Colla, Paolo |
| Zdroj: |
Nucleosides, Nucleotides & Nucleic Acids; April 2000, Vol. 19 Issue: 4 p705-722, 18p |
| Abstrakt: |
AbstractContinuing our studies on the structure-activity relationships (SAR) of 4-iodo-1-β-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR), the ribofuranosyl moiety has been substituted with acyclic chains, namely 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]-pyrazole derivatives (4, 5and 8, 9respectively), with the 2′-deoxy-β-D-ribofuranosyl group (12and 13) and finally with the 2′,3′-dideoxy-D-glycero-pentofuranosyl-moiety (16and 17). None of the new compounds display any interesting biological activity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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