| Autor: |
Cantrell, Charles, Groweiss, Amiram, Gustafson, Kirk, Boyd, Michael |
| Zdroj: |
Natural Product Research; October 1999, Vol. 14 Issue: 1 p39-46, 8p |
| Abstrakt: |
A new staurosporine analog, 4'-N-demethyl-11-hydroxystaurosporine (1), has been isolated by cytotoxicity-guided fractionation of an organic extract of the prosobranch mollusk Coriocella nigra. The known staurosporine derivative 3,11-dihydroxystaurosporine (2) was also isolated from this extract. Concurrent investigations of Coriocella hibyae resulted in the isolation of two known compounds, lamellarins C (3) and U (4). The structures of 1, 2, 3 and 4 were elucidated by spectroscopic methods and the compounds were evaluated for cytotoxicity against 10 human tumor cell lines. Compounds 1 and 2 demonstrated potent cytotoxic activity with IC50's ranging from approximately 2 to 66 ng/mL. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
