| Autor: |
Hartwell, D. W., Butterfield, C. E., Frenette, P. S., Kenyon, B. M., Hynes, R. O., Folkman, J., Wagner, Denisa |
| Zdroj: |
Microcirculation; 1998, Vol. 5 Issue: 2 p173-178, 6p |
| Abstrakt: |
Objectives: Several observations reported earlier indicated that the selectins, in particular E-selectin, might be involved in angiogenesis; however, mice deficient in the endothelial selectins develop normally. To clarify the role of endothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice. Methods: Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor α were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice. Results: The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice. Conclusion: The endothelial selectins are not essential in experimentally induced angiogenesis in vivo. |
| Databáze: |
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