| Autor: |
Nyquist, R. M., Eberhardt, A. S., Silks, L. A., III, Li, Z., Yang, X., Swanson, B. I. |
| Zdroj: |
Langmuir; February 2000, Vol. 16 Issue: 4 p1793-1800, 8p |
| Abstrakt: |
Mixed monolayers of thiol-terminated poly(ethylene glycol) (PEG) and thioacetyl GM1 glycolipid on Au(111) were examined utilizing atomic force microscopy, infrared spectroscopy, and grazing incidence X-ray diffraction to determine the composition, structure, and morphology and to characterize the specific and nonspecific interactions with protein. These monolayer architectures are robust and are readily controlled to provide a network of receptor GM1 in the PEG-terminated matrix. However, we also find significant levels of nonspecific and nonnative protein binding that render this simplistic model system unsuitable for highly sensitive biosensor device applications. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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