| Autor: |
Tamkun, John W., Deuring, Renate, Scott, Matthew P., Kissinger, Mark, Pattatucci, Angela M., Kaufman, Thomas C., Kennison, James A. |
| Zdroj: |
Cell; February 1992, Vol. 68 Issue: 3 p561-572, 12p |
| Abstrakt: |
The brahma(brm) gene is required for the activation of multiple homeotic genes in Drosophila. Loss-of-function brmmutations suppress mutations in Polycomb, a repressor of homeotic genes, and cause developmental defects similar to those arising from insufficient expression of the homeotic genes of the Antennapedia and Bithorax complexes. The brmgene encodes a 1638 residue protein that is similar to SNF2SWI2, a protein involved in transcriptional activation in yeast, suggesting possible models for the role of brm in the transcriptional activation of homeotic genes. In addition, both brm and SNF2 contain a 77 amino acid motif that is found in other Drosophila, yeast, and human regulatory proteins and may be characteristic of a new family of regulatory proteins. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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