An Improved Large-Scale Preparation of Benzimidazole-2-Sulfonic Acids and 2-Chlorobenzimidazoles.‡

Autor: Hinkley, JackM., Porcari, AnthonyR., Walker, JohnA., Swayze, EricE., Townsend*, LeroyB.
Zdroj: Synthetic Communications; May 1998, Vol. 28 Issue: 9 p1703-1712, 10p
Abstrakt: AbstractAn improved method for the preparation of benzimidazole-2-sulfonic acids from 2-mercaptobenzimidazoles has been developed which utilizes aqueous sodium percarbonate. 2-Chlorobenzimidazoles were obtained in high yield from the corresponding sulfonic acids upon reaction with PCl5in POCl3on a gram-mole scale.‡ Dedicated to Henry Koppel.
Databáze: Supplemental Index