| Autor: |
B. Williams, Russell, Norris, Andrew, S. Miller, James, Birkinshaw, Chris, Ratovoson, Fidy, Andriantsiferana, Rabodo, E. Rasamison, Vincent, G. I. Kingston, David |
| Zdroj: |
Journal of Natural Products; February 2007, Vol. 70 Issue: 2 p206-209, 4p |
| Abstrakt: |
Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescensled to the isolation of four new clerodane diterpenoids, designated caseanigrescens A−D (1−4). These compounds were subject to hydrolysis to dialdehydes when stored in CDCl3. The structures of compounds 1−4were determined using 1D and 2D NMR spectroscopy. All four compounds showed moderate cytotoxicity to the A2780 human ovarian cancer cell line, with an IC50range of 0.83−1.4 M. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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