| Autor: |
Wong, W. C., Sun, W., Cui, W., Chen, Y., Forray, C., Vaysse, P. J.-J., Branchek, T. A., Gluchowski, C. |
| Zdroj: |
Journal of Medicinal Chemistry; May 4, 2000, Vol. 43 Issue: 9 p1699-1704, 6p |
| Abstrakt: |
Cyclohexylamino oxazoline 1 (AGN 190837), an analogue of 2 (Bay a6781), is a potent α2 adrenoceptor agonist. On the basis of a design generated by receptor−ligand modeling, a number of cyclohexyl and norbornyl analogues were synthesized wherein the propyl group of 1 was replaced by phenylalkyl subsituents. This resulted in compound 6 being an α2c selective agonist, as well as 7 and 9 being α2a/α2c selective. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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