| Autor: |
Tecle, H., Barrett, S. D., Lauffer, D. J., Augelli-Szafran, C., Brann, M. R., Callahan, M. J., Caprathe, B. W., Davis, R. E., Doyle, P. D., Eubanks, D., Lipiniski, W., Mirzadegan, T., Moos, W. H., Moreland, D. W., Nelson, C. B., Pavia, M. R., Raby, C., Schwarz, R. D., Spencer, C. J., Thomas, A. J., Jaen, J. C. |
| Zdroj: |
Journal of Medicinal Chemistry; July 2, 1998, Vol. 41 Issue: 14 p2524-2536, 13p |
| Abstrakt: |
The synthesis and SAR of a series of (Z)-(±)-1-azabicyclo[2.2.1]heptan-3-one, O-(3-aryl-2-propynyl)oximes are described. The biochemistry and pharmacology of 24Z (PD 142505) and its enantiomers are highlighted. 24Z is functionally an m1-selective muscarinic agonist. Efficacy and m1 selectivity reside in the R enantiomer, (R)-24Z (CI-1017). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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