| Autor: |
Wilkerson, W. W., Dax, S., Cheatham, W. W. |
| Zdroj: |
Journal of Medicinal Chemistry; December 5, 1997, Vol. 40 Issue: 25 p4079-4088, 10p |
| Abstrakt: |
A series of nonsymmetrically substituted cyclic ureacarboxamides was synthesized and evaluated for antiviral activity as a function of the inhibition of HIV-protease. Selected protease inhibitors were also evaluated for oral bioavailability. The synthesis, pharmacology, quantitative structure−activity relationship (QSAR), and pharmacokinetics for the series will be discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
