| Autor: |
Orr, G. F., Musso, D. L., Kelley, J. L., Joyner, S. S., Davis, S. T., Baccanari, D. P. |
| Zdroj: |
Journal of Medicinal Chemistry; April 11, 1997, Vol. 40 Issue: 8 p1179-1185, 7p |
| Abstrakt: |
Structure−activity relationship studies on a series of 1-((2-hydroxyethoxy)methyl)-5-(3-(substituted-phenoxy)benzyl)uracils as inhibitors of murine liver uridine phosphorylase have led to compounds with IC50s as low as 1.4 nM. The two most potent compounds, 10j (3-cyanophenoxy) and 11f (3-chlorophenoxy) were tested in vivo for effects on steady-state concentrations of circulating uridine in mice and rats. Both compounds were substantially more efficacious than BAU (5-benzylacyclouridine) both in vitro and in vivo. |
| Databáze: |
Supplemental Index |
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