| Autor: |
Merhi, G., Colleman, A. W., Devissaguet, J.-P., Barratt, G. M. |
| Zdroj: |
Journal of Medicinal Chemistry; October 25, 1996, Vol. 39 Issue: 22 p4483-4488, 6p |
| Abstrakt: |
Macrophages can become cytotoxic toward tumor cells when activated by immunomodulators. Three different muramyl peptides were synthesized: one hydrolyzable lipophilic ester derivative (MTP-Chol) and two nonhydrolyzable lipophilic ether derivatives (MTP-octadecane and MTP-heptadecafluorooctadecane). Activation of the RAW 264.7 cell line was studied by measuring nitrite production as an indication of NO-synthase activity. The lipophilic ester derivative, incorporated within nanocapsules, was as active as free muramyl dipeptide, whereas the lipophilic ether derivatives were unable to activate macrophages. MTP-octadecane in micellar form was not capable of inducing macrophage cytotoxicity either. These results indicate that lipophilic muramyl peptides need to be hydrolyzed to yield a hydrosoluble metabolite in order to activate macrophages. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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