| Autor: |
Harfenist, M., Heuser, D. J., Joyner, C. T., Batchelor, J. F., White, H. L. |
| Zdroj: |
Journal of Medicinal Chemistry; April 26, 1996, Vol. 39 Issue: 9 p1857-1863, 7p |
| Abstrakt: |
Inhibition of monoamine oxidase A (MAO A) is believed to cause antidepressant and possibly antianxiety effects. The previous paper had developed structure−activity relationships (SAR) for in vitro MAO A inhibition by tricyclic N-arylamides.l It is shown in this paper that the same in vitro SAR can be carried over to tricyclics whose potentially toxic amide function is replaced by an appropriately substituted imidazoline, a 1,2,4- or 1,3,4-oxadiazole, or an alkylated tetrazole moiety. Dialysis of the inhibitor from the enzyme was used as a measure of reversibility which correlates with a low ability to cause a blood pressure rise with ingested tyramine (cheese effect). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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