| Autor: |
de Keyser, F., Elewaut, D., De Wever, N., Bensbaho, K., Cuvelier, C. |
| Zdroj: |
Bailliere's Clinical Rheumatology; February 1996, Vol. 10 Issue: 1 p25-39, 15p |
| Abstrakt: |
The process of lymphocyte trafficking is mainly regulated by receptors that belong to a group of molecules referred to as adhesion molecules. These molecules can be divided, according to their molecular structure, into three broad families: the integrins; the selectins; and the immunoglobulin superfamily members. The @a4@b7 integrin is expressed on some lymphocytes with hallmarks of guttropism. @a4@b7, among others, serves as a ligand for the mucosal vascular addressin MadCAM-1, which is selectively expressed on mucosal lymphoid organ high endothelial venules and on gut lamina propria venules. It is tempting to believe that related integrin receptors play a crucial role in the recirculation of activated lymphocytes between the gut mucosa and the synovial membrane. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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