Down-regulated in adenoma mediates apical Cl-/HCO3−exchange in rabbit, rat, and human duodenum

Autor: Jacob, Petra, Rossmann, Heidi, Lamprecht, Georg, Kretz, Alexandra, Neff, Christina, Lin-Wu, Elena, Gregor, Michael, Groneberg, David A., Kere, Juha, Seidler, Ursula
Zdroj: Gastroenterology; March 2002, Vol. 122 Issue: 3 p709-724, 16p
Abstrakt: Duodenal bicarbonate secretion is in part mediated by an apical Cl−/HCO3−exchanger of unknown molecular nature. The recently discovered dra(down-regulated in adenoma) gene encodes a transport protein (DRA) for SO42−, Cl−, and HCO3−. The aim of this study was to investigate whether DRA may be the duodenal apical CI−/HCO3−exchanger.
Databáze: Supplemental Index