| Autor: |
Talmi, Y.P., Merrick, Y., Bedrin, L., Waller, A., Horowitz, Z., Adunski, A., Brenner, H.J., Kronenberg, J. |
| Zdroj: |
European Journal of Cancer; November 1995, Vol. 31 Issue: 6 pS95-S95, 1p |
| Abstrakt: |
The incidence of synchronous or metachronous second primary malignancies (SPM) arising in the lungs following laryngeal cancer varies from 1.4–10.6% of cases. Conversely, to date, only 15 cases of a laryngeal SPM following lung cancer have been reported. We have conducted a prospective, preliminary study in 23 terminal lung cancer patients in a hospice setting in order to assess the incidence of a laryngeal SPM. No laryngeal tumors were observed. Even if under-diagnosed and under-reported, this entity is anecdotal in nature, even when considering the overall poor general survival rates of lung cancer. A lung SPM following laryngeal cancer may be explained by common risk factors such as smoking. However, this plausible theory of “field cancerization” does not seem to work both ways. Multimodality treatment or genetic factors may also playa role in the sequence of mucosal changes leading to neoplasia. Our results are presented in light of the general incidence of SPM in our country. Possible hypothesis for the lack of laryngeal SPM following lung cancer will be discussed. |
| Databáze: |
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