| Autor: |
Friedberg, W., Cearley, J. E., Neas, B. R., Faulkner, D. N., Coleman, R. L. |
| Zdroj: |
International Journal of Radiation Biology; 1970, Vol. 17 Issue: 5 p449-458, 10p |
| Abstrakt: |
Mice immunized to Hymenolepis nana were exposed to 950, 1150, 1350 or 1450 R x-radiation, then injected with syngeneic marrow from non-immune donors. Other immunized mice were exposed to 700 R but were not given marrow. To test for persistence of immunity, the mice were challenged with H. nana eggs. Parasite larvae (cysticercoids) developed in only 3 (1 or 2 cysticercoids each) of 40 immunized-unirradiated control mice challenged with eggs. Cysticercoids developed on egg challenge in all unimmunized control mice.There was no difference in cysticercoid counts between immunized-un-irradiated controls and either the 700 R group or the mice exposed to 1150 R and given 40 × 106 marrow cells 1 day later. A small number of cysticercoids developed in most of the mice exposed to 1350 or 1450 R and given 40 × 106 marrow cells 1 day after irradiation. Cysticercoids also developed in most of a 950 R group given 0·5 × 106 marrow cells 1 day after irradiation and 40 × 106 cells 20 days later; the cysticercoid counts were not different from those in similarly immunized and irradiated mice given only 0·5 × 106 cells. Thus, no benefit was derived from the second injection of marrow (40 × 106 cells) delayed until 21 days after irradiation. In contrast, in immunized mice given 40 × 106 marrow cells 4 days after 950 R, cysticercoid counts were not different from those in immunized-unirradiated controls.The role of transplanted syngeneic marrow in promoting persistence of immunity acquired before irradiation is discussed. |
| Databáze: |
Supplemental Index |
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