| Autor: |
Mylonas, M., Malandrinos, G., Plakatouras, J., Hadjiliadis, N., Kasprzak, K. S., Krezel, A., Bal, W. |
| Zdroj: |
Chemical Research in Toxicology; September 17, 2001, Vol. 14 Issue: 9 p1177-1183, 7p |
| Abstrakt: |
CH3CO-Thr-Glu-Ser-His-His-Lys-NH2, a hexapeptide representing the 120−125 sequence of histone H2A, coordinates Cu(II) ions efficiently. Monomeric complexes are formed. In the major complex at physiological pH, CuH-1L, Cu(II) is coordinated equatorially through the imidazole nitrogen of the His-4 residue and the amide nitrogens of the Ser-3 and His-4 residues, and axially through the imidazole nitrogen of the His-5 residue. This complex reacts with H2O2 and the resulting reactive oxygen intermediate efficiently oxidizes 2-deoxyguanosine. The underlying mechanism involves the formation of Cu(III) and a metal-bound hydroxyl radical species. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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